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Services

Process simulation

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Services

Process simulation

Beyond the vessel, we use SuperPro Designer to simulate the entire bioprocess – from media preparation and fermentation to downstream processing and utilities. This connects reactor behavior to plant-wide performance and economics, so you understand how your process really behaves at industrial scale.

With dynamic process models and scenario analysis, you can de-risk scale-up, test debottlenecking options, and link technical assumptions directly to CAPEX, OPEX, and unit production costs – before you commit to equipment or steel.

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Your benefits

Stronger process insights

Transparent view of where value and cost are created across the complete process.

Faster, data-driven decisions

Compare process routes, capacities, and equipment options based on hard numbers.

Solid foundation for next steps

Robust input for techno-economic assessment, concept design, and project execution.

Explore our deep simulation expertise

Process Simulation for your bioprocess

We build flowsheet models of your upstream and downstream steps to predict performance, capacities, and bottlenecks. Using SuperPro Designer, we simulate batch and continuous operations, link mass and energy balances across the entire plant, and quantify how process changes impact throughput and cost.

Flowsheet modeling & balances

How process simulation adds value

We represent your complete bioprocess in a flowsheet, from media preparation and fermentation to downstream purification and utilities. This includes unit operations, recipes, changeover times, and cleaning. The model provides consistent mass and energy balances across all steps and reveals how constraints in one area affect the entire line.


What you get

  • Flowsheet model of upstream and downstream process
  • Mass and energy balances for key operating cases
  • Visibility of interdependencies between unit operations
Scale-up & debottlenecking scenarios

How process simulation adds value

We use the model to test scale-up options and identify bottlenecks before you build. Different vessel sizes, numbers of trains, and batch vs. continuous strategies can be evaluated quickly. This helps you compare process variants (e.g. different yields or recovery rates) and select robust configurations for industrial implementation.


What you get

  • Evaluation of scale-up concepts and plant capacities
  • Identification of bottlenecks and debottlenecking options
  • Comparison of process variants (batch vs. continuous, yields, recoveries)
Linking process to CAPEX, OPEX, and unit costs

How process simulation adds value

By connecting the simulation to cost data, we translate technical assumptions into CAPEX, OPEX, and unit production costs. Equipment sizes and utilizations inform investment needs, while material and utility consumptions drive operating costs. This creates a clear bridge from process design to economic performance.


What you get

  • Equipment sizing and utilization as input for CAPEX estimates
  • Material and utility consumption profiles for OPEX calculations
  • Unit production cost per scenario for comparison with TEA and business cases
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Got Questions? Let's talk.


bioprocessing@buhlergroup.com